Predicting protein structure classes from function predictions
نویسندگان
چکیده
منابع مشابه
Predicting protein structure classes from function predictions
MOTIVATION We introduce a new approach to using the information contained in sequence-to-function prediction data in order to recognize protein template classes, a critical step in predicting protein structure. The data on which our method is based comprise probabilities of functional categories; for given query sequences these probabilities are obtained by a neural net that has previously been...
متن کاملProFunc: a server for predicting protein function from 3D structure
ProFunc (http://www.ebi.ac.uk/thornton-srv/databases/ProFunc) is a web server for predicting the likely function of proteins whose 3D structure is known but whose function is not. Users submit the coordinates of their structure to the server in PDB format. ProFunc makes use of both existing and novel methods to analyse the protein's sequence and structure identifying functional motifs or close ...
متن کاملPredicting protein function from structure: unique structural features of proteases.
We have noted consistent structural similarities among unrelated proteases. In comparison with other proteins of similar size, proteases have smaller than average surface areas, smaller radii of gyration, and higher C(alpha) densities. These findings imply that proteases are, as a group, more tightly packed than other proteins. There are also notable differences in secondary structure content b...
متن کاملPredicting protein-protein interactions from primary structure
MOTIVATION An ambitious goal of proteomics is to elucidate the structure, interactions and functions of all proteins within cells and organisms. The expectation is that this will provide a fuller appreciation of cellular processes and networks at the protein level, ultimately leading to a better understanding of disease mechanisms and suggesting new means for intervention. This paper addresses ...
متن کاملComputational protein function predictions.
What is the role of this protein? Where does this protein localize in a cell? Are there any ligands that bind to this protein? If so, what are they? Which residues constitute a functional site of the protein? These questions, which in a broader sense seek the biological function of a protein, are fundamental and central in modern biology. Ultimately, the biological function of a protein needs t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Bioinformatics
سال: 2004
ISSN: 1367-4803,1460-2059
DOI: 10.1093/bioinformatics/btg483